In the present study nanoparticles of naproxen sodium were prepared for oral controlled release drug delivery using hydrophilic mucoadhesive polymer chitosan, showing appreciable controlled release and favorable physico-chemical properties required for easy oral administration. Incorporation efficiency of all formulations of nanoparticles was analyzed. In-vitro dissolution studies were carried out to study release of drug from nanoparticles in pH 7.4 phosphate buffer. The mechanisms influencing the drug release rate were adsorption, diffusion, hydrophilicity of drug and affinity of the drug for polymer. The release pattern shows anomalous behavior, as further confirmed by Higuchi plots. The formulations were characterized by Scanning Electron Microscopy for their size and morphological features. The Formulations were characterized by IR and TLC. From these studies it was confirmed that there is no interaction of the drug with the polymer. Mucoadhesion of the formulation to pig-intestinal mucosa was investigated
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